Eastern Lake Ontario Environmental Research Group 2000 (cont'd from eloerg.tripod.com/waupoos)

Air Pollution overrides Ancestral Genes, Globe, March 2018
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Point O turbines 99% Down the Drain, CCSAGE, July 7, 2016
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Lighthouses of eastern Lake Ontario, new book by Marc Seguin, March 2016
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Valerie Langer: Thirty years of effort pays off on the B.C. coast, Feb 1,2016
Trillium log, 6th annual ELO expedtion, September 2015
Trillium Wind Corp intent on Spoliation of eastern Lake Ontario and Main Duck Isle, June 2015
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Ostrander: fiasco, or snafu? you decide, December 2013
Ostrander rises again, Noli illegitimi carborundum, December 2013
British Petroleum backing off Cape Vincent after a decade of aggression? December 2013
Turbines best Bald Eagles in U.S law, December 2013
SARStock 10 years after, letter to editor, August 2003
Trillium log September 2013: Surfin' USA: Hanging Ten in a Hughes 29
ERT Post mortem: Garth Manning lets it all hang out, August 2013
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Great Lakes United turns thirty, goes down, RIP GLU, July 29, 2013
ERT decision, Ostrander turns turtle, goes down, July 3, 2013
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Minister of Env on Lake Ontario Off shore wind turbine status, June 2013
Lake Ontario water level control plan, June 2013
Play by Play, Part II, APPEC Ostrander ERT Appeal, June 2013
Ostrander ERT June 2013, Appendix VI, an indirect cause of human morbidity and mortality ?
ELOERG Presentation to Ostrander ERT, Part II, Human Health, May 2013
The Dirty E-Word, Terry Sprague, Picton Gazette, April 2013
Toxics in Great Lakes Plastic Pollution, April 2013
Bill Evans on Birds and Wind farms, April 2013
Mayday, Naval Marine Archive, April 2013
Experimental Lakes Area, Kenora, Closing by Federal Gov't, March 2013
Fishing Lease Phase out on Prince Edward Point, March 2013
Windstream makes $1/2 Billion NAFTA claim, March 2013
Play by Play, PECFN Ostrander ERT Appeal, March 2013
Offshore Wind turbine moratorium 2 years later, The Star, Feb 2013
ELOERG ERT submission on Ostrander: Appendix V: Pushing the Envelope of the MoE SEV, Feb 2013
Wente on Wind and Bald Eagle mugging, Globe and Mail, February 2, 2013
Sprague on Wind and Bald Eagle mugging, Picton Gazette, Jan 25, 2013
Cry Me a River over a Few Bats: Submission to Env Review Tribunal, ELOERG, January 2013
Lake Ontario's Troubled Waters: U of Michigan GLEAM, January 2013
Letter to Minister of Environment re: Ostrander, January 2013
No Balm in Gilead: Ostrander IWT's as Trojan Horses, January 2013
Ostrander Turbines: another Christmas gift by the MoE, Dec 2012
Occupational carcinogens: Ontario Blue Collar breast cancer study, November 2012
Fresh water fish Extinctions, Scientific American,November 2012
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Frack the What ? November 2012
$ 2 1/4 Billion Trillium Power lawsuit knockback Appeal, November 2012
Canada Centre for Inland Waters decimated, October 2012
Birds, Bats, Turbines, and the Environmental Commissioner of Ontario, October 2012
Ecological public health, the 21st centurys big idea? British MedicalJournal Sept1,2012
Trillium log, Sept 2012
George Prevost, Saviour of the Canadas, 1812 - 1814. June 2012
The Victory at Picton: Bicentennial Conference on War of 1812-1814, Differing Perspectives, May 2012
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Genetic study of Quebec residents finds air pollution trumps ancestry

CHRISTOPHER KATSAROV/THE GLOBE AND MAIL
IVAN SEMENIUK
SCIENCE REPORTER
PUBLISHED 24 HOURS AGO UPDATED MARCH 6, 2018

Air pollution leaves its mark on the human body, not just in the throats and lungs of those who breathe it in, but in their very DNA, a newly published Canadian study has found. The work provides a unique window into how environmental exposures can switch various genes on or off, creating a gene expression signature that may interact with or override other inherited factors and even offer an early signal of future health problems.

"We were extremely surprised," said Philip Awadalla of the Ontario Institute for Cancer Research in Toronto, who led the study, published Tuesday in the journal Nature Communications. "Unequivocally what you'll see is that gene expression signatures follow where you live rather than your ancestry."

While it's long been known that proximity to air pollution can increase the risk of respiratory illness, including asthma and lung cancer, those epidemiological associations typically require huge populations to become evident and they say nothing about an individual's personal risk level.
What is notable about the Canadian study is that it was able to draw out a correlation with air pollution at a stage that precedes visible illness and that was evident in a sample size of just 1,000 individuals living in the province of Quebec.

Those individuals were of French-Canadian descent living in Montreal, Quebec City and the Saguenay region. Their common ethnicity helped to reduce variables in their genetic makeup. Nevertheless, by using whole genome sequencing to read the participants' DNA, the team was able to distinguish between participants who hailed from different locations.

Next, the team deduced which genes were being expressed by reading the RNA – the molecule that carries instructions from DNA to other parts of the cell – found in the participants' blood samples. At first, they expected that genetic background would play the deciding role in which genes were expressed, Dr. Awadalla said. However they soon discovered an environmental effect that was far stronger and correlated directly to air-pollution exposure, particularly fine particulate matter and nitrogen dioxide, which is associated with automobile exhaust. The fact that the gene expression factors that turned up in the study are known to be involved in lung function strengthened the team's conclusion that air pollution was the culprit.
The results show that someone who was born in Saguenay but who grew up in Montreal will develop a genetic expression signature along with associated risk factors that more closely resemble those of a native Montrealer.

The analysis also showed that genetic background was not entirely absent, because it had a measureable effect on modulating the environment-driven gene expression. This has interesting implications for precision medicine, an emerging paradigm that relies on genetic information to predict the likelihood of disease and guide treatment when illness strikes.

"This gets to the future of risk prediction," said Stephen Montgomery, a geneticist at Stanford University in California who was not involved in the study. "It's not just what's in your genome, but what you're exposed to."
Dr. Montgomery added that the Canadian study shows that companies that offer personal genetic sequencing to provide individuals with information on their ancestry and genetic predispositions are only capturing part of the story. It's conceivable that in the future, health-care providers will combine a patient's genome with an "expose-ome" that reveals gene expression, using the combination of the two to understand whether a disease risk is present.

"That's really what precision health is about," Dr. Awadalla said. "You want to capture these things before people are in the doctor's office and having to be treated."

The study is part of a larger effort known as the Canadian Partnership for Tomorrow Project (CPTP), which has collected environmental, lifestyle and genetic data from 300,000 individuals – roughly 1 per cent of Canada's population – and is tracking outcomes related to the development and progression of cancer and chronic diseases.

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Eastern Lake Ontario Environmental Research Group