Eastern Lake Ontario Environmental Research Group 2000 (cont'd from eloerg.tripod.com/waupoos)

Air Pollution overrides Ancestral Genes, Globe, March 2018
Slide to Extinction, Chris Humphrey, letter to Globe, October 31, 2018
Peter Galbraith, FRCP, obituary, October 2017
White Pines on Death Bed, Bruce Bell, Intelligencer, July 17,2018
Thucydides Trap, letter to Globe, May 2018
Great Lakes toxics down, SUNY Oswego/Clarkson U, April 2018
Machine subversion of democracy, letter to Globe, April 2018
Air Pollution overrides Ancestral Genes, Globe, March 2018
Olympian Cathal Kelly, letter to Globe, March 2018
Environmentalists seeking unemployment, letter to Globe, February 2018
Less is more on Bike Lanes, National Post, January 2018
Tramadol, 10 years on, Globe and Mail, November 2017
White Stripes: Belleville bicycle lanes, letters, November 2017
Occupational Cancers, CCO research results, Globe and Mail, October 2017
Big Pharmoney and Canadian Drug Use Guidelines, Globe and Mail, June 21, 2017, Kelly Grant
Oxycontin, 20 years on, letter to Globe, May 2017
Lake Ontario wind turbines to remain on hold? Feb 2017
Obituary, Raold Serebrin, September 2016
Sartorial slip or signal? letter to Globe editor, October 2016
Weapons of mass distraction, letter to Globe editor, Oct 2016
Point O turbines 99% Down the Drain, CCSAGE, July 7, 2016
Point O turbines Dead and Damned, PECFN, July 6, 2016
Rabid diplomat, letter to Globe, May, 2016
More on bats: rabid rocker? letter to Globe, January 2016
Lighthouses of eastern Lake Ontario, new book by Marc Seguin, March 2016
Continuing corporate windpower malfeasance: Windstream and Trillium Corp, Feb 2016
Amherst Island: the next fine mess, Feb 2016
Valerie Langer: Thirty years of effort pays off on the B.C. coast, Feb 1,2016
Trillium log, 6th annual ELO expedtion, September 2015
Trillium Wind Corp intent on Spoliation of eastern Lake Ontario and Main Duck Isle, June 2015
Turtles rule? Ontario Court of Appeal Decision: Turtlegate, April 2015
Obituaries, Mary Terrance (Luke) Hill, January 2015; Valerie Ingrid (Hill) Kaldes, July 2015
Ontario Court of Appeal turtle hearing, December 2014
Trillium Log, 5th annual ELO expedition, September 2014
Planetary public health manifesto, The Lancet, March 2014
Ostrander Bioblitz, butterfly inventory walk, August 10, 2014
Victory at Cape Vincent: British Petroleum withdraws turbine proposal, February 2014
Stay of execution granted by Ontario Court of Appeal, March 2014
Never say die: Will the Court of Appeal let the Ostrander Phoenix fly free again? March 2014
Divisional Court ruling in Ostrander: turtles belly up, Trojan horses win, February 2014
Lafarge 2020, pushing the air envelope again, Hazardous waste as cement kiln fuel proposal, Jan2014
Another fine mess in Port Hope: municipal waste incinerator proposal, January 2014
Ostrander: fiasco, or snafu? you decide, December 2013
Ostrander rises again, Noli illegitimi carborundum, December 2013
British Petroleum backing off Cape Vincent after a decade of aggression? December 2013
Turbines best Bald Eagles in U.S law, December 2013
SARStock 10 years after, letter to editor, August 2003
Trillium log September 2013: Surfin' USA: Hanging Ten in a Hughes 29
ERT Post mortem: Garth Manning lets it all hang out, August 2013
ERT post mortem: Cheryl Anderson lets it all hang out, August 2013
ERT Post Mortem: Ian Dubin lets it all hang out, August 2013
Great Lakes United turns thirty, goes down, RIP GLU, July 29, 2013
ERT decision, Ostrander turns turtle, goes down, July 3, 2013
PECFN Thankyou, and Appeal for funds, July 6, 2013
Minister of Env on Lake Ontario Off shore wind turbine status, June 2013
Lake Ontario water level control plan, June 2013
Play by Play, Part II, APPEC Ostrander ERT Appeal, June 2013
Ostrander ERT June 2013, Appendix VI, an indirect cause of human morbidity and mortality ?
ELOERG Presentation to Ostrander ERT, Part II, Human Health, May 2013
The Dirty E-Word, Terry Sprague, Picton Gazette, April 2013
Toxics in Great Lakes Plastic Pollution, April 2013
Bill Evans on Birds and Wind farms, April 2013
Mayday, Naval Marine Archive, April 2013
Experimental Lakes Area, Kenora, Closing by Federal Gov't, March 2013
Fishing Lease Phase out on Prince Edward Point, March 2013
Windstream makes $1/2 Billion NAFTA claim, March 2013
Play by Play, PECFN Ostrander ERT Appeal, March 2013
Offshore Wind turbine moratorium 2 years later, The Star, Feb 2013
ELOERG ERT submission on Ostrander: Appendix V: Pushing the Envelope of the MoE SEV, Feb 2013
Wente on Wind and Bald Eagle mugging, Globe and Mail, February 2, 2013
Sprague on Wind and Bald Eagle mugging, Picton Gazette, Jan 25, 2013
Cry Me a River over a Few Bats: Submission to Env Review Tribunal, ELOERG, January 2013
Lake Ontario's Troubled Waters: U of Michigan GLEAM, January 2013
Letter to Minister of Environment re: Ostrander, January 2013
No Balm in Gilead: Ostrander IWT's as Trojan Horses, January 2013
Ostrander Turbines: another Christmas gift by the MoE, Dec 2012
Occupational carcinogens: Ontario Blue Collar breast cancer study, November 2012
Fresh water fish Extinctions, Scientific American,November 2012
Great Lakes Toxics revisited, November 2012
Frack the What ? November 2012
$ 2 1/4 Billion Trillium Power lawsuit knockback Appeal, November 2012
Canada Centre for Inland Waters decimated, October 2012
Birds, Bats, Turbines, and the Environmental Commissioner of Ontario, October 2012
Ecological public health, the 21st centurys big idea? British MedicalJournal Sept1,2012
Trillium log, Sept 2012
George Prevost, Saviour of the Canadas, 1812 - 1814. June 2012
The Victory at Picton: Bicentennial Conference on War of 1812-1814, Differing Perspectives, May 2012
Carleton Island and the 1812, letter to the Globe, October 2011
Queen's Fine Arts Department Succumbs, letter to Principal, December 2011
Mr. Kumar and the Super 30, November 2011
Letters, Articles and Projects from the Nineties
Alban Goddard Hill, web site manager

Enter subhead content here

Genetic study of Quebec residents finds air pollution trumps ancestry


Air pollution leaves its mark on the human body, not just in the throats and lungs of those who breathe it in, but in their very DNA, a newly published Canadian study has found. The work provides a unique window into how environmental exposures can switch various genes on or off, creating a gene expression signature that may interact with or override other inherited factors and even offer an early signal of future health problems.

"We were extremely surprised," said Philip Awadalla of the Ontario Institute for Cancer Research in Toronto, who led the study, published Tuesday in the journal Nature Communications. "Unequivocally what you'll see is that gene expression signatures follow where you live rather than your ancestry."

While it's long been known that proximity to air pollution can increase the risk of respiratory illness, including asthma and lung cancer, those epidemiological associations typically require huge populations to become evident and they say nothing about an individual's personal risk level.
What is notable about the Canadian study is that it was able to draw out a correlation with air pollution at a stage that precedes visible illness and that was evident in a sample size of just 1,000 individuals living in the province of Quebec.

Those individuals were of French-Canadian descent living in Montreal, Quebec City and the Saguenay region. Their common ethnicity helped to reduce variables in their genetic makeup. Nevertheless, by using whole genome sequencing to read the participants' DNA, the team was able to distinguish between participants who hailed from different locations.

Next, the team deduced which genes were being expressed by reading the RNA – the molecule that carries instructions from DNA to other parts of the cell – found in the participants' blood samples. At first, they expected that genetic background would play the deciding role in which genes were expressed, Dr. Awadalla said. However they soon discovered an environmental effect that was far stronger and correlated directly to air-pollution exposure, particularly fine particulate matter and nitrogen dioxide, which is associated with automobile exhaust. The fact that the gene expression factors that turned up in the study are known to be involved in lung function strengthened the team's conclusion that air pollution was the culprit.
The results show that someone who was born in Saguenay but who grew up in Montreal will develop a genetic expression signature along with associated risk factors that more closely resemble those of a native Montrealer.

The analysis also showed that genetic background was not entirely absent, because it had a measureable effect on modulating the environment-driven gene expression. This has interesting implications for precision medicine, an emerging paradigm that relies on genetic information to predict the likelihood of disease and guide treatment when illness strikes.

"This gets to the future of risk prediction," said Stephen Montgomery, a geneticist at Stanford University in California who was not involved in the study. "It's not just what's in your genome, but what you're exposed to."
Dr. Montgomery added that the Canadian study shows that companies that offer personal genetic sequencing to provide individuals with information on their ancestry and genetic predispositions are only capturing part of the story. It's conceivable that in the future, health-care providers will combine a patient's genome with an "expose-ome" that reveals gene expression, using the combination of the two to understand whether a disease risk is present.

"That's really what precision health is about," Dr. Awadalla said. "You want to capture these things before people are in the doctor's office and having to be treated."

The study is part of a larger effort known as the Canadian Partnership for Tomorrow Project (CPTP), which has collected environmental, lifestyle and genetic data from 300,000 individuals – roughly 1 per cent of Canada's population – and is tracking outcomes related to the development and progression of cancer and chronic diseases.

Enter supporting content here

Eastern Lake Ontario Environmental Research Group