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CMAJ on PMRA, November 2023 |
EV as empty vessel in car sewers, Eric Reguly, Globe & Mail, May 20, 2023 |
Comic Piccini opera, Redux, Ontario auditor general Env Report, Globe & Mail, May 18, 2023 |
Venal or Venial? letter to Globe, May 16, 2023 |
"Cry me a river over a few bats", Redux, Globe & Mail, May 12,2023 |
Greenbelt "Scam": Barbarian Ford invasions, Globe & Mail, May 12, 2023 |
Barbarian Ford invasions case: City of Belleville Bell Creek dvlpt, Intelligencer, April 25, 2023 |
Road building projects in Wales, UK, cancelled as climate clangers, the Guardian, Feb 14, 2023 |
Unpublshed letter to Globe, 1996 opioids revisited, February 6, 2023 |
Cathal Kelly on climate charade, Globe & Mail, January 27, 2023 |
Ontario Bill 23, letter to the Premier, and Todd Smith MPP, Nov 24, 2022 |
Canola conundrum, letter to Globe & Mail, October 2022 |
3rd (Canadian) arm of U.S. Air Pollution Health Effects Study, the Guardian, Aug 12, 2022 |
Atomic awe and Boris blight, letter to Globe, July 11, 2022 |
Your !!*^%! car, Part II, Globe and Mail editorial, July 16, 2022 |
Your !!*^%! car, Part I, Globe and Mail, June 20, 2022 |
CAPE report on fossil fuels, Globe and Mail, June 9, 2022 |
Traffic Air Pollution Health Effects report, CAPE, April 2022 |
EU Bans Toxics, the Guardian, April 2022 |
Comic Piccini opera: Ontario Auditor General Environment Report, November 2021 |
......RIP Trillium...... November 16, 2021 |
Covid-19 Parlour Sessions 2020/2021, April 1, 2021 |
Mitch Podoluk, Obituary, Globe and Mail, September 2019 |
Notice to (Big Bay) Mariners, August 2019 |
Air Head, Globe and Mail, August 2019 |
Leon Redbone, RIP, June 2019 |
Ontario Endangered Species Act at risk, letter to Rod Phillips, April 2019 |
Slide to Extinction, Chris Humphrey, letter to Globe, October 31, 2018 |
Peter Galbraith, FRCP, obituary, October 2017 |
White Pines on Death Bed, Bruce Bell, Intelligencer, July 17,2018 |
Thucydides Trap, letter to Globe, May 2018 |
Great Lakes toxics down, SUNY Oswego/Clarkson U, April 2018 |
Machine subversion of democracy, letter to Globe, April 2018 |
Air Pollution overrides Ancestral Genes, Globe, March 2018 |
Olympian Cathal Kelly, letter to Globe, March 2018 |
Environmentalists seeking unemployment, letter to Globe, February 2018 |
Less is more on Bike Lanes, National Post, January 2018 |
Tramadol, 10 years on, Globe and Mail, November 2017 |
White Stripes: Belleville bicycle lanes, letters, November 2017 |
Occupational Cancers, CCO research results, Globe and Mail, October 2017 |
Big Pharmoney and Canadian Drug Use Guidelines, Globe and Mail, June 21, 2017, Kelly Grant |
Oxycontin, 20 years on, letter to Globe, May 2017 |
Lake Ontario wind turbines to remain on hold? Feb 2017 |
Obituary, Raold Serebrin, September 2016 |
Sartorial slip or signal? letter to Globe editor, October 2016 |
Weapons of mass distraction, letter to Globe editor, Oct 2016 |
Point O turbines 99% Down the Drain, CCSAGE, July 7, 2016 |
Point O turbines Dead and Damned, PECFN, July 6, 2016 |
Rabid diplomat, letter to Globe, May, 2016 |
More on bats: rabid rocker? letter to Globe, January 2016 |
Lighthouses of eastern Lake Ontario, new book by Marc Seguin, March 2016 |
Continuing corporate windpower malfeasance: Windstream and Trillium Corp, Feb 2016 |
Amherst Island: the next fine mess, Feb 2016 |
Valerie Langer: Thirty years of effort pays off on the B.C. coast, Feb 1,2016 |
Trillium log, 6th annual ELO expedtion, September 2015 |
Trillium Wind Corp intent on Spoliation of eastern Lake Ontario and Main Duck Isle, June 2015 |
Turtles rule? Ontario Court of Appeal Decision: Turtlegate, April 2015 |
Obituaries, Mary Terrance (Luke) Hill, January 2015; Valerie Ingrid (Hill) Kaldes, July 2015 |
Ontario Court of Appeal turtle hearing, December 2014 |
Trillium Log, 5th annual ELO expedition, September 2014 |
Planetary public health manifesto, The Lancet, March 2014 |
Ostrander Bioblitz, butterfly inventory walk, August 10, 2014 |
Victory at Cape Vincent: British Petroleum withdraws turbine proposal, February 2014 |
Stay of execution granted by Ontario Court of Appeal, March 2014 |
Never say die: Will the Court of Appeal let the Ostrander Phoenix fly free again? March 2014 |
Divisional Court ruling in Ostrander: turtles belly up, Trojan horses win, February 2014 |
Lafarge 2020, pushing the air envelope again, Hazardous waste as cement kiln fuel proposal, Jan2014 |
Another fine mess in Port Hope: municipal waste incinerator proposal, January 2014 |
Ostrander: fiasco, or snafu? you decide, December 2013 |
Ostrander rises again, Noli illegitimi carborundum, December 2013 |
British Petroleum backing off Cape Vincent after a decade of aggression? December 2013 |
Turbines best Bald Eagles in U.S law, December 2013 |
SARStock 10 years after, letter to Globe, August 2003 |
Trillium log September 2013: Surfin' USA: Hanging Ten in a Hughes 29 |
ERT Post mortem: Garth Manning lets it all hang out, August 2013 |
ERT post mortem: Cheryl Anderson lets it all hang out, August 2013 |
ERT Post Mortem: Ian Dubin lets it all hang out, August 2013 |
Great Lakes United turns thirty, goes down, RIP GLU, July 29, 2013 |
ERT decision, Ostrander turns turtle, goes down, July 3, 2013 |
PECFN Thankyou, and Appeal for funds, July 6, 2013 |
Minister of Env on Lake Ontario Off shore wind turbine status, June 2013 |
Lake Ontario water level control plan, June 2013 |
Play by Play, Part II, APPEC Ostrander ERT Appeal, June 2013 |
Ostrander ERT June 2013, Appendix VI, an indirect cause of human morbidity and mortality ? |
ELOERG Presentation to Ostrander ERT, Part II, Human Health, May 2013 |
The Dirty E-Word, Terry Sprague, Picton Gazette, April 2013 |
Toxics in Great Lakes Plastic Pollution, April 2013 |
Bill Evans on Birds and Wind farms, April 2013 |
Mayday, Naval Marine Archive, April 2013 |
Experimental Lakes Area, Kenora, Closing by Federal Gov't, March 2013 |
Fishing Lease Phase out on Prince Edward Point, March 2013 |
Windstream makes $1/2 Billion NAFTA claim, March 2013 |
Play by Play, PECFN Ostrander ERT Appeal, March 2013 |
Offshore Wind turbine moratorium 2 years later, The Star, Feb 2013 |
ELOERG ERT submission on Ostrander: Appendix V: Pushing the Envelope of the MoE SEV, Feb 2013 |
Wente on Wind and Bald Eagle mugging, Globe and Mail, February 2, 2013 |
Sprague on Wind and Bald Eagle mugging, Picton Gazette, Jan 25, 2013 |
Cry Me a River over a Few Bats: Submission to Env Review Tribunal, ELOERG, January 2013 |
Lake Ontario's Troubled Waters: U of Michigan GLEAM, January 2013 |
Letter to Minister of Environment re: Ostrander, January 2013 |
No Balm in Gilead: Ostrander IWT's as Trojan Horses, January 2013 |
Ostrander Turbines: another Christmas gift by the MoE, Dec 2012 |
Occupational carcinogens: Ontario Blue Collar breast cancer study, November 2012 |
Fresh water fish Extinctions, Scientific American,November 2012 |
Great Lakes Toxics revisited, November 2012 |
Frack the What ? November 2012 |
$ 2 1/4 Billion Trillium Power lawsuit knockback Appeal, November 2012 |
Canada Centre for Inland Waters decimated, October 2012 |
Birds, Bats, Turbines, and the Environmental Commissioner of Ontario, October 2012 |
Ecological public health, the 21st centurys big idea? British MedicalJournal Sept1,2012 |
Trillium log, Sept 2012 |
George Prevost, Saviour of the Canadas, 1812 - 1814. June 2012 |
The Victory at Picton: Bicentennial Conference on War of 1812-1814, Differing Perspectives, May 2012 |
Carleton Island and the 1812, letter to the Globe, October 2011 |
Queen's Fine Arts Department Succumbs, letter to Principal, December 2011 |
Mr. Kumar and the Super 30, November 2011 |
Letters, Articles and Projects from the Nineties |
Alban Goddard Hill, web site manager |
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Genetic study of Quebec residents finds air pollution trumps ancestry
CHRISTOPHER KATSAROV/THE GLOBE AND MAIL IVAN
SEMENIUK SCIENCE REPORTER PUBLISHED 24 HOURS AGO UPDATED MARCH 6, 2018
Air pollution leaves its mark on the
human body, not just in the throats and lungs of those who breathe it in, but in their very DNA, a newly published Canadian
study has found. The work provides a unique window into how environmental exposures can switch various genes on or off, creating
a gene expression signature that may interact with or override other inherited factors and even offer an early signal of future
health problems.
"We were extremely surprised," said Philip Awadalla of the Ontario Institute for Cancer
Research in Toronto, who led the study, published Tuesday in the journal Nature Communications. "Unequivocally what you'll
see is that gene expression signatures follow where you live rather than your ancestry."
While it's long been
known that proximity to air pollution can increase the risk of respiratory illness, including asthma and lung cancer, those
epidemiological associations typically require huge populations to become evident and they say nothing about an individual's
personal risk level. What is notable about the Canadian study is that it was able to draw out a correlation with air pollution
at a stage that precedes visible illness and that was evident in a sample size of just 1,000 individuals living in the province
of Quebec.
Those individuals were of French-Canadian descent living in Montreal, Quebec City and the Saguenay region.
Their common ethnicity helped to reduce variables in their genetic makeup. Nevertheless, by using whole genome sequencing
to read the participants' DNA, the team was able to distinguish between participants who hailed from different locations.
Next,
the team deduced which genes were being expressed by reading the RNA – the molecule that carries instructions from
DNA to other parts of the cell – found in the participants' blood samples. At first, they expected that genetic
background would play the deciding role in which genes were expressed, Dr. Awadalla said. However they soon discovered an
environmental effect that was far stronger and correlated directly to air-pollution exposure, particularly fine particulate
matter and nitrogen dioxide, which is associated with automobile exhaust. The fact that the gene expression factors that turned
up in the study are known to be involved in lung function strengthened the team's conclusion that air pollution was the culprit. The
results show that someone who was born in Saguenay but who grew up in Montreal will develop a genetic expression signature
along with associated risk factors that more closely resemble those of a native Montrealer.
The analysis also showed
that genetic background was not entirely absent, because it had a measureable effect on modulating the environment-driven
gene expression. This has interesting implications for precision medicine, an emerging paradigm that relies on genetic information
to predict the likelihood of disease and guide treatment when illness strikes.
"This gets to the future of risk
prediction," said Stephen Montgomery, a geneticist at Stanford University in California who was not involved in the study.
"It's not just what's in your genome, but what you're exposed to." Dr. Montgomery added that the Canadian study
shows that companies that offer personal genetic sequencing to provide individuals with information on their ancestry and
genetic predispositions are only capturing part of the story. It's conceivable that in the future, health-care providers will
combine a patient's genome with an "expose-ome" that reveals gene expression, using the combination of the two to
understand whether a disease risk is present.
"That's really what precision health is about," Dr. Awadalla
said. "You want to capture these things before people are in the doctor's office and having to be treated."
The
study is part of a larger effort known as the Canadian Partnership for Tomorrow Project (CPTP), which has collected environmental,
lifestyle and genetic data from 300,000 individuals – roughly 1 per cent of Canada's population – and
is tracking outcomes related to the development and progression of cancer and chronic diseases.
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Enter supporting content here
Eastern Lake Ontario Environmental Research Group
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